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Some patients receiving high doses may develop balance disorder (loss of balance), kidney damage, and hearing loss

These major metabolic effects are further enhanced through multiple synergistic interactions such as improving insulin signaling, inhibiting chronic low-grade inflammation, remodeling of adipose tissue function, and reducing oxidative stress

doi: 10.1007/S10753-013-9732-X 217 SackRBFroehlichJL

Strategies for formulating concentrations of the fluids for intravenous infusion that create isotonic or hypertonic solutions are more desirable than using hypotonic solutions

Most studies report good tolerability (mainly mild GI side effects )

The final spectra were baseline, background corrected and presented as the mean of residue ellipticity