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J Invest Dermatol (1982) 78:2069

To view a copy of this licence, visit About this article Cite this article Gharib, F.A.E.L., Osama, k., Sattar, A.M.A.E

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Expression of D620N VPS35 in cortical neurons led to impaired neurite outgrowth and induced dopaminergic neurodegeneration in a novel virus-mediated rat model ( + ) and rotenone was significantly increased in the overexpression of WT and D620N VPS35 models ( via formation of mitochondrial-derived vesicles (MDVs) and played an important role in mediating transport of the vesicles from mitochondria to peroxisomes and lysosomes ( VPS35 mutations resulted in mitochondrial fragmentation and neuronal loss in neurons in vivo and in vitro (Wang et al., 2016)

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In addition, endogenous oxidants produced by different pathophysiological processes in the lung and anywhere in the body also increased the oxidative burden