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Supplementing with oral glutathione under conditions in which intracellular glutathione status is compromised can restore tissue glutathione and promote ROS metabolism, thereby mitigating tissue atrophy, according to a 2017 study published in the World Journal of Gastroenterology

bioRxiv2025 Oct 7

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The oxidative stress linked to hyperglycemia impairs insulin signaling and -cell function, contributing to insulin resistance, a hallmark of T2DM [4]

Its levels in the body can be affected by lifestyle factors such as diet, stress, and exercise, as well as environmental pollutants