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Lipid-lowering therapies such as statins and PCSK9 inhibitors, particularly angiopoietin-like 3 antibodies and antisense oligonucleotide therapy, significantly reduce cardiovascular risk 76,259,260 and provide additional benefits beyond cholesterol reduction, including anti-inflammatory and endothelial protective effects

4,18,19 Nonetheless, pathological changes in the brain begin during the preclinical stage, decades before clinical symptoms

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