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In rodent studies, degeneration may also be applicable to chronic debility, but more often it is used to reflect acute or chronic cytological alterations with characteristic morphological features

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Notably, in the setting of high-frequency and prolonged sympathetic activation such as during acute myocardial ischemia, additional sympathetic co-transmitters other than norepinephrine (NE) are co-released from sympathetic post-ganglionic efferent fibers, including ATP, galanin and neuropeptide Y (NPY) (Herring 2015)

Clonal selection may facilitate the initial survival of malignant cells during anticancer therapy, permitting a minority of cancer cells to acquire additional drug-resistant mutations, thereby facilitating disease progression

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