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Conflicting results for transplant-related mortality were obtained when the myeloablative regimen was changed from busulfan and cyclophosphamide to treosulfan, fludarabine and thiotepa (TreoFluT), and this change did not improve GVHD and graft failure in mixed-class groups of patients [87], [88]

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The announcement shocked health experts because the FDAs usual approval process, which is lengthy and rigorous, has been bypassed

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