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Description

Unlike the live SP, which displayed remarkable antioxidant effects and osteoclastogenesis-inhibitory properties, both SP powder and boiled SP lost these biological functions (Supplementary Figs

This relies on mitochondrial Ca 2+ accumulation, which is underpinned by the activation of pyruvate dehydrogenase kinase 4 (PDK4) and the subsequent stabilisation of key proteins involved in mitochondria-SR interactions, namely inositol 1,4,5-triphosphate receptor 1, 75-kDa glucose-regulated protein and voltage-dependant anion channel 1 (Thoudam et al., 2019)