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A study by Hou et al., found that type II alveolar epithelial cells release SHH, which influences macrophage M2 activation through osteopontin production, causing pulmonary fibrosis

3.2.2 BNIP3/NIX mediated mitophagy NIX, a protein with 50% homology to BNIP3 (Matsushima et al., 1998), binds to the mitochondrial outer membrane through its carboxyl transmembrane domain, thereby initiating mitophagy under ischemic or hypoxic conditions

This combination approach, targeting multiple pathways involved in appetite regulation and energy balance, represents a promising direction in obesity treatment

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