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In a placebo-controlled pilot study, 30 patients received 1 million IU/day subcutaneous IL-2 every other day for 2 weeks, which was followed by a 2-week break, and this 4-week period was repeated twice ( post hoc per-protocol analysis which excluded patients from two sites, where the SRI-4 response rate was 100% in the placebo group showed a statistically significant difference in connection with the primary endpoint, which encourages further investigations (86)

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doi: 10.1016/j.cell.2006.02.015 101 ZhangXChaoPZhangLXuLCuiXWangSet al

QSM/MC/IEA 117

Rudnick DA, Perlmutter DH