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Abstract Acute ischemic stroke is the third leading cause of death in industrialized countries and the most frequent cause of permanent disability in adults worldwide

[44] Zhao J, Yang PC, Yang H, Wang ZB, El-Samahy M, Wang F, et al

Methylene blue treatment was first used in 1891 when German physician and Nobel laureate Paul Ehrlich explored methylene blues use as a staining agent and potential therapeutic compound