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Clinical trials show average weight loss of 16% to 22.5% of body weight over 72 weeks, depending on dose

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NNMT inhibition as a therapeutic strategy has been explored in industry pharmaceutical pipelines (including a Pfizer program for non-alcoholic fatty liver disease that was reportedly discontinued in early clinical development), but no NNMT inhibitor has reached regulatory approval to date

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This synthetic peptide fragment derived from human growth hormone (amino acids 176-191) has been specifically engineered to isolate the fat-metabolizing properties of growth hormone while completely eliminating effects on insulin-like growth factor 1 (IGF-1), blood glucose regulation, and tissue growth