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130 Less mtDNA copy number and more mtDNA damage are observed in SLE, which is associated with disease durations and prognosis in some SLE patients

These findings not only confirm the immunogenicity of ferroptosis but also expand the list of ferroptotic DAMPs responsible for its immunogenicity by adding CRT and ATP to the previously identified danger molecule decorin 20 and various oxidized products, including oxygenated phosphatidylethanolamine 70

The transcription factor Forkhead box O3a (FOXO3a) also regulates multiple antioxidant genes and is reduced in COPD lungs as a result of phosphoinositide-3-kinase (PI3K) activation [18,50]

Guy et al., 2007

V., Gui, D

Metabolic abnormalities in PE directly influence lipid metabolic pathways involved in ferroptosis (Kagan et al., 2017)