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Older patients tend to have smaller veins, so placing an IV in someone over age 65 is more difficult than in a younger person

This means more of the active compound is available to interact with cellular receptors for a longer period

doi: 10.5411/wji.v12.i2.15 [DOI] [Google Scholar] 188

Segar notes, Many of these interactions are based on mechanistic data, animal data, and isolated case reports. This means that many of the potential interactions in the list above havent been confirmed in human studies