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Compared to MT1 and alpha-MSH, the cyclic form of MT2 boosts affinity towards various melanocortin receptors, namely MC1R and MC4R

Pathological oral mucosal melanin hyperpigmentations include those related to tobacco smoke, to certain systemic diseases or syndromes, to inflammatory processes, to certain drugs, and to developmental, benign, or malignant changes in melanocytes [4, 6, 1013]