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Central to this defense are enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and molecules like glutathione, which collectively neutralize harmful reactive species, safeguard cellular integrity, and support overall cellular function

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RNA-seq analysis RNA-seq was performed on tissues using Genomics Research Center (GRC) at URMC and the Bauer Core Facility at Harvard University

CNS lipids are susceptible to oxidative damage (Niki, 2014) and lipoperoxidation generates high levels of HNE, MDA (Radak et al., 2011) and F2-isoprostane (F2-IsoPS) (Milne et al., 2007

Cattarinussi G, Delvecchio G, Maggioni E, Bressi C, Brambilla P

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