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PMID 16452303

Mild, temporary diarrhea is the main side effect of ursodeoxycholic acid (Zakko 2018)

The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair

Cellular senescence is a common mechanism for AKI-CKD transition and progression of various glomerular diseases, and targeting senescent cells or related pathways may be a potential therapeutic strategy (Zhang et al., 2024)