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Description

Since no covalent bonds are needed, this delivery method may carry several molecules of an anticancer medication without appreciably altering the antibody's capacity to target tumors

R.BohovP.et al (2021)

doi: 10.2147/DMSO.S216791

10.1073/pnas.1508220112 Proc

In particular, carrier family 38 member 1 (SLC38A1)- and SLC1A5-mediated l-glutamine (but not d-glutamine) uptake and subsequent glutaminase 2 (GLS2, but not GLS1)-mediated glutamate production is required for cystine deprivation- or erastin-induced ferroptosis 40 (Fig