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Agric Water Manage 208:132139

BMC Med 2007

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Mol Cell 75:2638.e3

The ortho-dihydroxyl arrangement facilitates hydrogen atom donation and stabilization of phenoxy radicals through resonance delocalization, interrupting radical chain reactions

It can alleviate H 2 O 2 -induced p38 MAPK and NF-B activation through a reactive oxygen species (ROS)-dependent pathway ( At the site of vascular injury, platelets adhere to and aggregate in the exposed endothelial extracellular matrix (ECM) ( In vitro and in vivo experiments revealed that a lack of GPVI receptors or blockade of the GPVI receptors effectively inhibits platelet activation and reduces thrombosis and that these interventions are accompanied by only a slight bleeding tendency, probably because GPVI is expressed only on platelets and their precursor megakaryocytes ( Luteolin has significant antiplatelet activity and antithrombotic effects, but whether luteolin affects platelet-GPVI interaction and inhibits platelet activation and oxidative stress in thrombosis has not been reported