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Similar to RMT, the BBB entry occurs with an invagination of cell membrane holding the bonded molecule, followed by endosomal formation and transport from the luminal to the abluminal side, and finally with the exocytosis of the cargo (Figure 3E

Although E2AIF is expected to cause a frame-shift, resulting in loss of AIF protein, those humans with a small portion of E2AIF variant did not show obvious neurological abnormalities

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Furthermore, this review provides a perspective for future research that may contribute to the development of new drugs for neurodegenerative disease treatments

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Alpha-lipoic acid effectively neutralizes a variety of free radicals, including oxygen radicals and ionized metals