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Targeted metabolomics in HeLa cells expressing Lb NOX ( a ), Ec STH ( b ) and mito Ec STH ( c )

Low Dose Ezetimibe, 2.5mg/day, lowered LDL from 135mg/dl to 72, LDL particle number from 1450 to 1060, APOb from 138 to 81 mg/dl, LP(a) from 90 nmol/L to 81, HDL unchanged at about 55mg/dl, Triglycerides unchanged at about 52 mg/dl

2015;5:a019679

Freezing reconstituted solutions is generally discouraged because it can lead to aggregation and loss of activity due to ice crystal formation, especially if the solution isn't specifically formulated with cryoprotectants