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Preclinical data show that gestational Zn deficiency in rodents caused significant alternation in the production of and expression of NMDA subunits, brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) which caused memory and learning impairments later in life (171)

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Apart from the low propensity of the GSAAT(C168S) and GSAAT(C190S) mutants to dimerize, these single substitution mutants not only failed to promote redox-dependent dimerization and oxidation of monomeric GSAAT, but even prevented it

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