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However, the approach was also used for the improvement of brain delivery of therapeutic agents with extracellular targets including a neurotransmitter dopamine, competitive antagonist of the glycine site of the NMDA receptor 7-chlorokynurenic acid, serotonin-norepinephrine reuptake inhibitor venlafaxine and inhibitor of the GABA transporter nipecotic acid (Table II, III)

DNAzymes or deoxyribozymes are considered therapeutic agents themselves for various diseases because they have the ability to recognize and cleave their substrates 101,102

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Notably, this molecular restructuring correlates with a pronounced age-associated decline in mitochondrial respiratory supercomplexes (mtRSCs) assembly, suggesting a potential mechanistic basis for progressive mitochondrial dysfunction during aging (Warnsmann et al

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