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Adaptive responses to hypoxia involve the regulation of gene expression by HIF-1, the expression, stability and transcriptional activity of which increase exponentially on lowering p O 2 [52, 53, 56, 80, 81]

DCI affects approximately 30% of patients and is the leading cause of morbidity and mortality after surviving the initial aneurysm rupture [8]

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Wei, Microchimica Acta 186, (2019)