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For example, curcumin has been evaluated in Phase II clinical studies in pancreatic cancer and colorectal cancer patients, where oral doses up to 8 g/day demonstrated acceptable safety but limited systemic exposure, highlighting pharmacokinetic challenges

J Am Coll Nutr 2003;22:43-51

The DNA fragment encoding SYNCRIP was amplified from SKOV3 cDNA by PCR technique using primer pair SalI-SYNCRIP/SYNCRIP-KpnI and cloned into SalI/KpnI sites of pTagGFP2-C plasmid (Evrogen, #FP191) to generate pTagGFP2-SYNCRIP plasmid

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Specific chain lengths also contribute to the observed selectivity of dyes towards tumor tissues

It also works when given orally