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(Shengma) has been shown to significantly elevate tight junction proteins Claudin-1, Occludin, and ZO-1, as well as the MUC2, through inhibition of PI3K/Akt/NF-B signaling pathway to enhance the intestinal mucosal barrier to reduce pathogen invasion (Wu et al., 2025)

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We reported earlier that ACD in older humans is associated with glutathione (GSH) deficiency, oxidative stress (OxS), mitochondrial dysfunction, glucose dysmetabolism and inflammation, and that supplementing GlyNAC (glycine and N-acetylcysteine) improved these defects

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