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In certain embodiments, the dose is between 0.001 mg/kg patient weight to about 15 mg/kg per kg patient weight per administration, or 0.01 mg/kg to about 1.5 mg/kg

Disclosures: Jing He: Nothing to Disclose, Boqiang Liu: Nothing to Disclose, Liang Shi: Nothing to Disclose, Xiujun Cai: Nothing to Disclose 707 AI-BASED DIGITAL PATHOLOGY SHOWS THAT DENIFANSTAT IMPROVES MULTIPLE PARAMETERS OF FIBROSIS AND REDUCES PROGRESSION TO CIRRHOSIS IN MASH PATIENTS WITH F2/F3 FIBROSIS RESULTS: OF THE FASCINATE-2 STUDY Mary Rinella 1 Wen-Wei Tsai 2 Katharine Grimmer 2 Eduardo Martins 2 Pierre Bedossa 3 Kutbuddin Akbary 4 Dean Tai 4 Marie O'Farrell 2 George Kemble 2 Rohit Loomba 5 , 1 The University of Chicago, 2 Sagimet Biosciences, 3 Liverpat, 4 HistoIndex, 5 University of California, San Diego Background: AI-based digital pathology is an advanced tool that complements conventional histopathology by allowing precise and quantitative analysis of histological changes

To assess the effects of amino acid deprivation, cells were cultivated using modified amino acid-free DMEM powder (PAN-Biotech) supplemented with individual amino acids (Sigma-Aldrich) as indicated, at final concentrations used in standard DMEM

Immunomodulation aims to restore normal immune balance by adjusting specific pathways without broadly weakening the immune system

doi: 10.1186/s13024-022-00548-6 37 CosolaC.RocchettiM

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