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MMP-1 is capable of breaking down the integrated fibrillar collagen, whereas MMP-2, MMP-3 and MMP-9 break down the fragments and degraded forms (44-46)

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Agencies such as the FDA and EMA now apply nanotechnology guidance that emphasize detailed physicochemical characterization, stability profiling, immunotoxicity assessment, and biodistribution studies, particularly for long-acting injectable systems like cabotegravir and rilpivirine [144]