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Although the specific activity of GS is normally 2 to 4 times that of GCL activity in normal liver (Lu et al., 1992b, Lu et al., 1999c), this may not be the case in other tissues

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doi: 10.1002/yea.1706 104 LuH.ChenH.TangX.YangQ.ZhangH.ChenY

It all comes down to the primary research objective

Interestingly, LATS1/2 depletion was able to silence the expression of the Wnt target gene, MYC , even in the APC mutant intestinal cells, making it a good candidate for intestinal tumor therapy

As the pedigree depicted autosomal recessive inheritance, homozygous and compound heterozygous variants were preferred but heterozygous variants were not ignored