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Species can differ substantially in absorption, transport, hepatic metabolism, renal handling and off-target effects

1996 May;53(5):441-8

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Cobalamin is the only B vitamin not present in plant materials [7]

The FDA label includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, contraindicating use in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2