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Future work should adopt longitudinal designs to assess therapeutic effects across temporal windows

Antioxidants like glutathione and precursors like NAC are at the forefront of this movement

Reduced expression of CXCR4, a novel renal cancer stem cell marker, is associated with high-grade renal cell carcinoma

The NQO1 bioactivatable drug, -lapachone, alters the redox state of NQO1 pancreatic cancer cells, causing perturbation in central carbon metabolism

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Tumor suppressor BRCA1-Associated Protein 1 (BAP1) is mutated in up to 25% of human CCAs and has been found to promote ferroptosis, an iron-dependent form of cell death driven by phospholipid peroxidation