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NO production increased in a concentration-dependent manner

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7.2.1 Non-monotonic dose-response relationships 7.2.1.1 Mechanistic understanding of NMDR effects Many EEDs exhibit non-monotonic dose-response curves where low-dose exposure produces greater biological effects than high-dose exposure (139)

A comprehensive evaluation is warranted to identify contributing factors, including assessment of surgical anatomy, eating patterns, physical activity levels, psychological factors, and metabolic parameters