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Cell Commun Signal 2017;15:3

Measurement of IGF-1 is complicated, by both the biology of IGF-1 and the recent need to differentiate the endogenous form of IGF-1, and the synthetic therapeutic forms developed to treat growth disorders

Any excess continues to circulate throughout the body

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Even though oocytes possess the capability to counteract this effect through the activation of intricate surveillance, repair, and proteolytic pathways, it is noteworthy that these defense systems are susceptible to age-related impairments, thereby diminishing their capacity to effectively eliminate proteins damaged by oxidation (Peters et al., 2020)