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Additional investigations are warranted to explore the fundamental mechanisms and validate the clinical significance of capsaicin as a specific intervention for modifying DNA methylation and expression patterns of genes associated with medical conditions (25)

doi: 10.1016/j.yrtph.2015.06.016, 222

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The majority of QIs was reduced back to the respective parent compound (50% of AQ-QI and 80% of DEAQ-QI), presumably by the action of endogenous antioxidants and/or reductases, e.g., quinone reductases ( Figure 5B )