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Although speculative, it could be hypothesised that this proposed increase in susceptibility of OPCs to ROS-induced damage compared to other brain cell types could, at least in part, be driven by ROS induced alterations in DNA methylation in these cells [6, 30, 32]

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16 These impaired DNA modifications can accelerate aging and cause neurodegenerative, carcinogenesis, autoimmune, cardiovascular, and other diseases

Ionizing radiation Most frequently, ionizing radiation is considered electromagnetic radiation that can cause damage to biological systems

TAMs are characterized by elevated glutamine utilization, which is reflected by their high expression of both glutamine transporters and catabolic enzymes 43,44