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Acta Neurochir

Rochard E, Barthes D

Inherit ydr495c vps3 Vacuolar sorting protein and segregation ygl227w vid30 Vacuolar import and degradation yil017c vid28 Vacuolar import and degradation yll040c vps 13 Protein involved in vacuolar sorting ylrll48w pep3 Class C complex, vacuolar biogenesis ylr396c vps33 Class C complex, vacuolar biogenesis yml097c vps9 Protein involved in vacuolar sorting yor036w pep 12 SARE-Syntaxin of the late endosome ygll24c monl Vacuolar protein sorting ygl223c cod3 Component of Sec34p-Sec35p complex ykl212w scl Phosphoinisotide phosphatase yerlSlc ubp3 Ubiquitin-specific protease yl047c spc72 Cytoplasmic plaque of spindle pole body ycl007c cwh36 Generation of mannoprotein layer yhr030c mpkl Serine/threonine protein kinase yjl095w bckl Serine/threonine protein kinase ynl225c Component of spindle pole body yor043w whi2 DA repair protein ybr036c csg2 Ca 2+ homeostasis protein (CHP) family ygr217w cchl Voltage-gated Ca 2+ channel ybr279w pfl Protein associated with RA polymerase II ybr289w snf5 Component of SWI-SF complex ydr448w d2 Component of SAGA & ADA complexes ygr252w gcn5 Component of SAGA & ADA complexes ylr226w bur2 Regulation of transcription yol004w sin3 Component of histone deacetylase B ypl254w hfil Component of the ADA complex ydr264c akrl Pheromone signaling pathway yil053w rhr2 D,L-glycerol phosphate phosphatase ynl280c erg24 C-14 sterol reductase ypl022w radl Nucleotide excision repairosome yal024c Itel Required for termination of M phase ydl023c Protein of unknown function ygll07c Protein of unknown function yil029c Protein of unknown function yil041w Protein of unknown function yil077c Protein of unknown function yil097w yvlO Protein of unknown function yilllOw Protein of unknown function ymr!23w pkrl Protein of unknown function yol027c Protein of unknown function Many of the mutants listed above are defective in vacuolar function, where glutathione degradation is known to occur

Crucially, this functional dichotomy is governed by spatial localization and kinetics

p53 functions as a tumor suppressor by halting cell cycle progression and by activating apoptosis in response to cellular damage

GLS2 is a tumor suppressor and a regulator of ferroptosis in hepatocellular carcinoma