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Effects of exercise training on the glutathione antioxidant system Alzahrani, T.F., et al

10.1093/oxfordjournals.molbev.a026406 51 MurataH.IharaY.NakamuraH.YodoiJ.SumikawaK.KondoT

Attention is focused on the reasons preclinical promise has not translated into clinical success, emphasizing the limitations of current research models, the urgent need for reliable biomarkers of mitochondrial dysfunction, and the complexity of targeting interconnected pathological networks

Consumption of GSH can promote ferroptosis by decreasing SLC7A11 and GPX4 expression in dopaminergic neurons of PD patients

Moreover, rats treated with 1% neohesperidin dihydrochalcone for 1 month showed reduced amygdala neuroinflammation via suppression of cAMP/PKA pathway activity, restoration of cortical 5-HT, DA, and NE levels, and reversal of anxiety- and depression-like behaviors (Jiang et al., 2023)