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Clinically, Su et al

In MPTP-induced mice, EGCG not only activates PI3K/Akt survival signaling but also inhibits the MAPK pathway to reduce neuroinflammation and neuronal apoptosis (54)

[5] [7] At dosages exceeding 5 grams, there is a potential risk for more severe adverse effects, including renal dysfunction, blood toxicity, and neurological symptoms

Neurochem Int 62(5):803819 Thangavelu L et al (2024) Non-coding RNAs in Parkinsons disease: regulating SNCA and alpha-synuclein aggregation

Since the KMPC1 signaling pathway in KDM5a is involved in cancer cell proliferation and metastasis, suppressed MPC1 levels may induce EMT