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SKU: 95211409205
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doi: 10.1371/journal.pone.0059051 22 LenerMRGuptaSScottRJTootsiMKulpMTammesooMLet al

Nowadays, extensive experiments and studies have been conducted on the combination of nanoparticles and biological compounds for treatment, but there is relatively little research on ferroptosis

ACSL4 catalyzes the reaction of PUFAs to polyunsaturated fatty acid-coenzyme A (PUFA-CoA), and then the PUFA-CoA undergoes esterification by lysophosphatidylcholine acyltransferase 3 (LPCAT3) to become polyunsaturated fatty acid-phospholipids (PUFA-PLs), which are then oxidized by reactive oxygen species (ROS) to cytotoxic phospholipid hydroperoxides (PL-OOH), leading to cell death through membrane modification (Liu et al., 2025