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Although it remains unknown as to how the inhibition of the interaction with BRD4 occurs in the context of full-length ASXL1, the intramolecular contacts with the C-terminal region of ASXL1 that occlude ASXL1 EBM could play a role

That also means side effects at higher doses are real, and earning your dose over time is not optional it's the strategy

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Short-term exposure to room temperature is generally fine (a few hours), but prolonged periods at higher temperatures can cause them to degrade and lose potency