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The peptide appears well-tolerated in research settings with no major toxicity identified

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Moreover, GHK-Cu significantly inhibited the LPS-induced phosphorylation of p38 MAPK and slightly decreased the phosphorylation of JNK1/2, while having no observable effect on ERK1/2

10.1152/physrev.00020.2005 210 SteeleT

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The peptide suppresses pro-inflammatory cytokines including TNF-, IL-6, and TGF-, which are key drivers of chronic low-grade inflammation (inflammaging) in older skin