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this association, however, was significantly influenced by body mass index (BMI), diabetes type, age, region, and sex (Zhao et al., 2013

[139] demonstrated that all-trans retinoic acid suppressed PI3K/Akt activity and increased the GSK-3-dependent degradation of phosphorylated -catenin, resulting in the differentiation of hepatic CSCs and increasing their sensitivity to docetaxel