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Beyond genetic mutations and aberrant cellular signaling, accumulating evidence shows that chronic inflammation is a critical driver of cancer initiation and progression, with nearly 25% of tumors believed to originate from persistent tissue inflammation [217]

Leite JS, Raizel R, Hypolito TM, Rosa TD, Cruzat VF, Tirapegui J

However, in the microcirculation, where RBCs are in close proximity to the vasculature and Hb becomes partially oxygenated, ROS released from neutrophils, macrophages, and endothelial cells can be taken up by RBCs

however, in HF, lactylation is viewed as a protective factor

Metwaly HH, Fathy SA, Abdel Moneim MM, Emam MA, Soliman AF, El-Naggar ME, Omara EA, El-Bana MA (2022) Chitosan and solid lipid nanoparticles enhance the efficiency of alpha-lipoic acid against experimental neurotoxicity

it has shown promise in those with AUDs, especially in patients with early-onset AUD