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In the absence of enough iron in cells, an iron starvation response begins, increasing iron availability by increasing TFCR1 and decreasing the levels of FTH and ferroportin (FPN) (34)

Hence, more and more studies in recent years have focused on the strategy targeting mitochondria in kidney diseases (Granata et al., 2015

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60 While these studies indicate a positive influence of lipids on the functionality and metabolism of CD8 + T cells in the TME, it is important to note that alterations to T-cell lipid metabolism might attenuate their antitumoral effects

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