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To investigate whether FBXO22 serves as a critical mediator of the biological functions of BPC157, we established FBXO22-knockdown HUVEC models via siRNA-mediated gene silencing

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2.2.2 Mechanisms linking increased Hcy levels to MetS Elevated Hcy levels exert inhibitory effects on the insulin signaling pathway, primarily by inducing IR through the cysteine-homocysteinylation of the pro-insulin receptor