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Additionally, the upstream regulators and specific isoforms involved in this pathway remain to be identified

Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA (2012) IRE1 cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2