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Use of Tesamorelin outside of approved clinical indications is not authorized in many jurisdictions

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In the 5xFAD mouse model, reduced secretion of Brain-Derived Neurotrophic Factor (BDNF) from astrocytes results in a 30% decrease in neuronal dendritic spine density and impaired cognitive function

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Science and Technology Development Plan Project of Jilin Province, China (20240601022RC) Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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