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Your body produces glucosamine naturally, but like collagen, this production decreases with age

Induction by glucose in vitro or in diabetic rats: Prevention and reversal by glutathione, Exp

Wang LK, Wu TJ, Hong JH, Chen FH, Yu J, Wang CC

GA decreases the activity of catalase (CAT), ascorbate peroxidase (APX), and superoxide dismutase (SOD), leading to reduced scavenging ability for ROS, consequently resulting in peroxidative damage of membranes followed by release of hydrolytic enzymes (Jones and Smirnoff, 2005

Nevertheless, the growing number of hereditary cases identified in adolescents and adults contradicts this assumption

The condition manifests as recurrent sprains, persistent feelings of giving way, and reduced confidence in ankle stability during activity