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Drawbacks/limitations Despite its promising effects, several limitations exist in this study

doi: 10.1002/cam4.601 399

The subsequent release of free fatty acids (FFAs) into circulation impairs insulin signaling across multiple peripheral tissues ( Table 2 Integrated analysis of adipocyte dysfunction: from molecular mechanisms to systemic impact

While the results of this clinical study have been submitted for publication, they are not yet publicly available

Studies suggest that CBD can reduce inflammation-induced inducible NOS (iNOS) expression while maintaining or enhancing endothelial NOS (eNOS)-mediated NO production, leading to decreased oxidative stress, improved endothelial function, and reduced neuroinflammation

One-electron oxidation of AA is also possible, generating a semi-dehydro-ascorbyl radical (Kocot et al., 2017)