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In contrast, it showed a higher glutamate level in the brain in a mouse model of Parkinsons disease [141]

Figure 2 In-depth exploration of these molecular mechanisms provides critical insights into macrophage ferroptosis and identifies potential therapeutic targets for atherosclerosis

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These drugs target cells in the cochlea, mostly hair cells, by increasing oxidative stress and induction of cochlear inflammatory processes and cell death, and generally produce permanent hearing loss

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Thus, the effect of CK1, PKC, and p38 MAPK varies from pro-survival in some erythrocyte precursors to pro-eryptotic in mature cells, which might be a consequence of missing downstream effectors in circulating erythrocytes