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The underlying mechanisms were investigated, leading to the discovery that in strains expressing high levels of gdhA mRNA, two promoters, gdhA P1 and gdhA P2, initiate transcription of gdhA

It should be noted that GSH ester tends to be enriched inside cells due to its hydrophobic nature and esterase-catalyzed hydrolysis of GSH ester to GSH

[5] Uniquely, ALA is often termed a universal antioxidant because it is soluble in both water and lipid environments, and it has the ability to regenerate other antioxidants such as vitamin C, vitamin E, and glutathione from their oxidized forms

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The level of OGD-induced ferroptosis in ADSCs was assessed according to the viability of cells treated with the ferroptosis inhibitor Ferrostatin-1 (Fer-1) 5 M, autophagy inhibitor 3-Methyladenine (3-MA) 5 mM, apoptosis inhibitor Z-VAD-FMK 10 M, necroptosis inhibitor Necrostatin-1 (Nec-1) 50 M, or ferroptosis activator erastin

Choose whichever timing you can maintain consistently without side effects